Cybergenic

Cancer gene co-occurrence and exclusivity in tumour cohorts, with confound controls and exact tests.

От сообществаРаботаетБез входаГлобальныйБесплатноТолько чтение

Что умеет

    Какие данные видит

    Нужен ли аккаунт

    Не нужен: сервер работает без входа

    Cancer gene co-occurrence and exclusivity in tumour cohorts, with confound controls and exact tests.

    Как подключить

    Как подключить Cybergenic к Claude

    Адрес сервера, который нужно вставить в настройках Claude:

    https://cybergenic.im/mcp?via=mcpregistry

    1. Откройте Claude (сайт claude.ai или приложение для компьютера).
    2. Перейдите в Настройки → Коннекторы (в английском интерфейсе: Settings → Connectors).
    3. Нажмите Добавить пользовательский коннектор (Add custom connector).
    4. Вставьте адрес сервера, скопированный ниже, в поле URL удалённого MCP-сервера и нажмите Добавить.
    5. В чате нажмите + → Коннекторы и включите новый коннектор.

    Пользовательские коннекторы доступны на тарифах Free, Pro, Max, Team и Enterprise. На Free можно добавить только один. В Team и Enterprise коннектор сначала добавляет владелец организации в Настройки организации → Коннекторы.

    Авторизация

    После нажатия Добавить откроется окно входа в сервис. Войдите под своим аккаунтом и подтвердите доступ. Пароль Claude не видит.

    Как подключить Cybergenic к ChatGPT

    Адрес сервера, который нужно вставить в настройках ChatGPT:

    https://cybergenic.im/mcp?via=mcpregistry

    1. Откройте ChatGPT в браузере (chatgpt.com). Нужен тариф Plus, Pro, Business, Enterprise или Edu.
    2. Один раз включите режим разработчика: Настройки → Приложения → Дополнительные настройки → Режим разработчика (Settings → Apps → Advanced settings → Developer mode).
    3. Откройте Настройки → Коннекторы и нажмите Создать (Create).
    4. Заполните форму: Название (любое), Описание (одна фраза, что делает сервис), URL MCP-сервера (скопируйте ниже).
    5. В поле Аутентификация выберите OAuth, если сервис требует вход, иначе Нет. Нажмите Создать.
    6. В новом чате откройте + → Приложения/Коннекторы и включите коннектор.

    Название раздела у OpenAI менялось (Connectors → Apps/Plugins). Если пункт называется иначе, ищите «режим разработчика» в настройках. В рабочих пространствах Business/Enterprise администратор должен разрешить пользовательские коннекторы.

    Авторизация

    При первом использовании ChatGPT откроет окно входа в сервис. Войдите и подтвердите доступ.

    Как подключить Cybergenic к Cursor

    Адрес сервера, который нужно вставить в настройках Cursor:

    https://cybergenic.im/mcp?via=mcpregistry

    Быстрый способ: нажмите кнопку Открыть в Cursor ниже, Cursor сам предложит добавить сервер.

    Вручную:

    1. В Cursor откройте Settings → Cursor Settings → MCP и нажмите Add new global MCP server.
    2. Вставьте JSON, скопированный ниже, в открывшийся файл ~/.cursor/mcp.json (для одного проекта: .cursor/mcp.json в корне проекта).
    3. Сохраните файл. Сервер появится в списке MCP; при необходимости пройдите авторизацию по кнопке рядом с ним.

    Авторизация

    Если сервис требует вход, рядом с сервером в списке MCP появится кнопка авторизации.

    Список инструментов сервера (9)

    Технические названия из tools/list. Нужны только разработчикам.

    lookup_gene_pairMeasured co-alteration statistics for two genes in every tumour cohort where Cybergenic's discovery scan tested the pair: tumours with both genes altered against the number expected, odds ratio, p-value and Benjamini-Hochberg q over that cohort's whole family of tested pairs, the confound control applied (molecular subtype, lineage or histology strata, with mutation burden conditioned on), and whether the pair passes the scan's own discovery gates. A direction is stated only where it is significant, consistent and at least a two-fold odds ratio, and cohorts are also counted by independent patient source (the two MSK cohorts overlap). Also returns Cybergenic's published findings on the pair with their verdicts and permalinks. Use it to answer whether two genes' driver mutations co-occur or are mutually exclusive in patient tumours. Associations in tumour sequencing, not causal or clinical evidence.
    gene_partnersThe genes whose driver mutations co-occur with, or are mutually exclusive with, a given gene in patient tumours, strongest first by Benjamini-Hochberg q, from every pair Cybergenic's discovery scan tested: one row per partner and independent patient source, with the tumours, observed and expected co-alteration and the odds ratio. By default only pairs the scan's own gates keep (significant, a real effect size, a consistent direction, enough tumours); set passing_only to false to include significant pairs that fail a gate. Filter by cancer, direction and q threshold. Use it to survey a gene's co-alteration landscape before looking up a specific pair. Associations in tumour sequencing, not causal or clinical evidence.
    search_findingsSearch Cybergenic's published findings: gene-pair co-occurrence and mutual exclusivity, survival associations, CRISPR gene dependencies and single-gene leads, each with the verdict the engine measured (strengthened, weakened, inconclusive, artifact risk or novel lead) and the reason for it. The query works like the site's search: exact gene symbols, cancer names or abbreviations (NSCLC, CRC, PDAC, TNBC), or both, and every term must match. Returns permalinks to cite and ids for get_finding.
    get_findingThe full record of one Cybergenic finding, by id or permalink: what was measured and in which cohort, the statistics (the 2x2 table, odds ratio, p and q), the verdict and why, the confound checks, how many papers mention the genes together, CRISPR dependency and survival facts when measured, the prediction locked for it in the hash-chained registry, the same question in other cohorts, and a citation. The hypothesis text is a model-written annotation, not evidence.
    get_track_recordCybergenic's live track record: how many predictions it has locked in its hash-chained registry before re-testing them, how many replicated in an independent cohort against matched controls (including the less-studied-pair subset), and how many findings currently pass every check as both strong and overlooked. Read it before describing how reliable the engine is; it states its own limits, including whether the replication comes from well-known biology.
    fisher_exact_testFisher's exact test for a 2x2 table [[a, b], [c, d]]: two-sided and both one-sided p-values (computed in log space, so a tiny p keeps its real exponent), the sample odds ratio, and the conditional maximum-likelihood odds ratio with its exact confidence interval (what R's fisher.test reports). For two genes: a = tumours with both altered, b = gene A only, c = gene B only, d = neither. Up to 100,000 observations. The same implementation as cybergenic.im/tools/fisher-exact-test.
    chi_square_testPearson chi-square test of independence for an r x c table of counts (2x2 up to 10x10), with Yates' correction for 2x2 tables and the G-test: statistic, degrees of freedom, p-value, expected counts, adjusted residuals, Cramér's V, whether Cochran's rule for the approximation holds, and Fisher's exact test when the table is 2x2. Empty rows and columns are dropped and reported.
    odds_ratio_relative_riskEffect sizes for a 2x2 table [[a, b], [c, d]] whose rows are two groups and whose columns are outcome yes and no: the odds ratio (Woolf interval, and the conditional exact interval), the relative risk (Katz interval), the risk difference (Newcombe interval) and the number needed to treat, at the chosen confidence level, plus Fisher's exact p. A zero cell applies the Haldane-Anscombe correction to the Woolf and Katz estimates, and the result says so.
    fdr_correctionMultiple-testing correction for a list of p-values: Benjamini-Hochberg q-values and Benjamini-Yekutieli, Holm, Hochberg and Bonferroni adjusted p-values, the number of discoveries at alpha for each method, and the Benjamini-Hochberg cutoff rank. Pass family_size when more tests were run than the p-values supplied (for example only the top hits were kept). Up to 10,000 p-values per call; the same implementation as cybergenic.im/tools/fdr-correction, verified against R p.adjust and statsmodels.