HLA-Verify
HLA nomenclature and match checks against a pinned IPD-IMGT/HLA release.
Community: Submitted by a user or imported; check the owner before granting accessOnlineAPI key requiredGlobalFreeRead-only
What it can do
What data it sees
Do you need an account
An API key from the service settings is required
HLA nomenclature and match checks against a pinned IPD-IMGT/HLA release. No patient identifiers.
Server tool list (10)
Raw names from tools/list. Only developers need these.
| verify_text | Scan HLA typing report text, or model output about HLA, for allele-shaped tokens and classify each one: valid / legacy (with modern form) / deleted (with successor) / fabricated. Nomenclature checking against a pinned IPD-IMGT/HLA release, not interpretation of a case. Use on any AI-generated or transcribed content mentioning HLA. Send the HLA content only, with patient identifiers removed first. |
| normalize_allele | Normalize one reported HLA allele name (any era) to current 2-field form, with G group, P group, serologic equivalent, and flags. |
| allele_info | Look up one exact name in the pinned release and return what it is: assigned (G/P group, first release, confirmed status, WMDA serology, null flag), valid_prefix (member count and sample), or deleted (successor). Not found if the name has never existed in any release. |
| match_score | Count a donor-recipient HLA match by the published counting rules (R1-R6): allele arithmetic over chromosomes, not a donor recommendation. recipient/donor: {"A": ["A*01:01","A*02:01"], "B": [...], ...} (two reported alleles per locus, any nomenclature era; allele strings only, no patient identifiers). framework: 6/6, 8/8, 10/10, 12/12, or antigen. Returns count, per-locus verdicts, GvH/HvG mismatch counts, and flags; unresolvable typing yields 'potential', never a confident count. |
| check_typing | QC-check one HLA typing (all loci) against the pinned release: resolves every reported allele, flags unresolvable/outdated/locus-mismatched/null alleles, flags too-many/single/homozygous per locus, computes the B-leader (-21 M/T) and KIR-ligand (C1/C2/Bw4) profile, and DRB3/4/5 expected-vs-reported. Nomenclature and internal-consistency checking of the report, not clinical interpretation. typing: {"A": ["A*01:01", "A*02:01"], "B": [...], "DRB1": [...], ...} (any nomenclature era; allele strings only, no patient identifiers). |
| donor_compat | Donor/recipient immunogenetic compatibility under two published rule sets: HLA-B leader match (-21 M/T, Petersdorf 2020) for a single HLA-B mismatch, and KIR ligand (C1/C2/Bw4) class comparison, computed over each side's full typing QC. Rule checking against published frameworks; it does not rank or recommend a donor. recipient/donor: {"A": [...], "B": [...], "C": [...], "DRB1": [...], ...} (allele strings only, no patient identifiers). Decision support only; not a medical device. |
| validate_gl_string | Validate and normalize a GL String (Genotype List, ^ | + ~ / grammar): resolves every allele token, flags outdated/unresolvable names and structural problems (mixed loci within a slash-list, a repeated locus within a haplotype or across ^ blocks, more than two haplotypes, differing loci across a genotype or genotype list, empty elements), and returns the normalized string. Grammar and nomenclature checking only; send allele names, not patient identifiers. |
| beta_signup | Put a user on the free public beta's notification list for paid API keys. Ask before calling: it records the address they give you. Re-signing the same address is safe (status already_recorded). Someone who needs a higher rate limit today should email hello@hlaverify.com for a beta key instead of waiting. |
| research_access | Apply for free HLA-Verify access for an academic or nonprofit lab. Ask before calling: it records the address, institution and use case you give it. Approval is manual: a person reads every application, so it is not instant and not guaranteed. If it is approved the applicant is emailed a single-use code that takes 100% off a subscription for 12 months at self-serve checkout, with no card and no contract. Re-applying with the same address is safe (status already_recorded) and never overwrites an application that has already been decided. Commercial labs should buy a tier at https://api.hlaverify.com/pricing instead. |
| about | What this server is and is not, what to send it, benchmark evidence for why to use it, the beta state, and terms. |